Synthesis and Structure-Chirality Relationship Analysis of Steroidal Quinoxalines to Design and Develop New Chiral Drugs

Of the utmost importance of chirality in organic compounds and drugs, present work reports structure-chirality relationship three steroidal quinoxalines, which were synthesised by condensing diaminobenzenes with cholestenone. All purified characterised varying analytical tools prior to their chiroptical analysis circular dichroism (CD) technique. The substituent groups on quinoxalines contributed determining properties compounds. positive Cotton effects have been observed CD spectra unsubstituted methyl-substituted indicated P helicity. Importantly, chloro-substituent produced different behaviour, can be attributed presence lone pairs electrons Cl atom. provides guidelines for chiral useful design develop potential molecules biological importance.